Pubmed: medical imaging

Pubmed: medical imaging

  • : Nonmediated, Label-Free Based Detection of Cardiovascular Biomarker in a Biological Sample. - pubmed: "medical imaging"
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    Nonmediated, Label-Free Based Detection of Cardiovascular Biomarker in a Biological Sample.

    Adv Healthc Mater. 2017 Jun 21;:

    Authors: Lee J, Shin S, Desalvo A, Lee G, Lee JY, Polini A, Chae S, Jeong H, Kim J, Choi H, Lee H

    Abstract
    Direct electrochemical (EC) monitoring in a cell culture medium without electron transporter as called mediator is attractive topic in vitro organoid based on chip with frequently and long-time monitoring since it can avoid to its disadvantage as stability, toxicity. Here, direct monitoring with nonmediator is demonstrated based on impedance spectroscopy under the culture medium in order to overcome the limitation of mediator. The applicability of EC monitoring is shown by detecting alpha-1-anti trypsin (A1AT) which is known as biomarkers for cardiac damage and is widely chosen in organoid cardiac cell-based chip. The validity of presented EC monitoring is proved by observing signal processing and transduction in medium, mediator, medium-mediator complex. After the observation of electron behavior, A1AT as target analyte is immobilized on the electrode and detected using antibody-antigen interaction. As a result, the result indicates limit of detection is 10 ng mL(-1) and linearity for the 10-1000 ng mL(-1) range, with a sensitivity of 3980 nF (log [g mL])(-1) retaining specificity. This EC monitoring is based on label-free and reagentless detection, will pave the way to use for continuous and simple monitoring of in vitro organoid platform.

    PMID: 28636127 [PubMed - as supplied by publisher]

  • : Ovarian reserve after fibroid embolization in premenopausal women. - pubmed: "medical imaging"
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    Ovarian reserve after fibroid embolization in premenopausal women.

    Minim Invasive Ther Allied Technol. 2017 Feb 24;:1-8

    Authors: Tsikouras P, Manav B, Koukouli Z, Trypsiannis G, Galazios G, Souftas D, Souftas V

    Abstract
    OBJECTIVE: To investigate the effect of uterine artery embolization (UAE) for fibroids on ovarian pool of premenopausal women.
    STUDY DESIGN: Prospective case control study.
    MATERIAL AND METHODS: One-hundred and twenty premenopausal women, aged between 40 and 50 years, who underwent UAE for symptomatic uterine fibroids and the same number of women, aged between 40 and 50 years, with symptomatic uterine fibroids, who were not offered treatment were recruited for this study. Hormonal status and ovarian reserve were evaluated by means of anti-Müllerian hormone (AMH) and follicle stimulating hormone (FSH) pre-procedural, three months, six months and 12 months after UAE.
    RESULTS: No statistically significant decrease was noted in AMH values 12 months post procedure and no statistical significant alterations in AMH values between the two groups.
    CONCLUSIONS: Even though the study results may not be able to confirm the preservation of ovarian reserve and normal menstruation after UAE in premenopausal women, it should be considered as a friendly to normal menstruation treatment option of symptomatic fibroids.

    PMID: 28635407 [PubMed - as supplied by publisher]

  • : Psychomotor skills assessment by motion analysis in minimally invasive surgery on an animal organ. - pubmed: "medical imaging"
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    Psychomotor skills assessment by motion analysis in minimally invasive surgery on an animal organ.

    Minim Invasive Ther Allied Technol. 2017 Feb 08;:1-9

    Authors: Hofstad EF, Våpenstad C, Bø LE, Langø T, Kuhry E, Mårvik R

    Abstract
    BACKGROUND: A high level of psychomotor skills is required to perform minimally invasive surgery (MIS) safely. To be able to measure these skills is important in the assessment of surgeons, as it enables constructive feedback during training. The aim of this study was to test the validity of an objective and automatic assessment method using motion analysis during a laparoscopic procedure on an animal organ.
    MATERIAL AND METHODS: Experienced surgeons in laparoscopy (experts) and medical students (novices) performed a cholecystectomy on a porcine liver box model. The motions of the surgical tools were acquired and analyzed by 11 different motion-related metrics, i.e., a total of 19 metrics as eight of them were measured separately for each hand. We identified for which of the metrics the experts outperformed the novices.
    RESULTS: In total, two experts and 28 novices were included. The experts achieved significantly better results for 13 of the 19 instrument motion metrics.
    CONCLUSIONS: Expert performance is characterized by a low time to complete the cholecystectomy, high bimanual dexterity (instrument coordination), a limited amount of movement and low measurement of motion smoothness of the dissection instrument, and relatively high usage of the grasper to optimize tissue positioning for dissection.

    PMID: 28635403 [PubMed - as supplied by publisher]

  • : Implementation of LI-RADS into a radiological practice. - pubmed: "medical imaging"
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    Implementation of LI-RADS into a radiological practice.

    Abdom Radiol (NY). 2017 Jun 20;:

    Authors: Siedlikowski ST, Kielar AZ, Ormsby EL, Bijan B, Kagay C

    Abstract
    Since its introduction in 2011, Liver Imaging Reporting and Data System (LI-RADS) has become an increasingly utilized method for radiologists to categorize lesions for hepatocellular carcinoma (HCC) in patients at risk (American College of Radiology, www.acr.org/quality-safety/resources/lirads 2016). This overview article presents insight into methods of incorporating LI-RADS into an existing clinical practice, highlighting concrete ways to establish this system as a mainstay in any radiologist's evidence-based armamentarium. We will focus on the importance of standardization to improve the value of our reporting. We will also discuss specific opportunities to favor adoption of LI-RADS including building a community of users composed of radiologists and referring physicians, forming a strategic vision, enlisting a team leader, overcoming barriers to adoption, communicating successes, integrating the system into the departmental culture, and learning from mistakes. The 2017 version of LI-RADS is the most recent update and is based on the most current medical imaging evidence. The details of these updates are described in other articles in this journal's edition. Efforts should be made to increase adherence and to enhance standardized use of LI-RADS internationally. Ultimately, the objective of LI-RADS is to prioritize patient care and optimize medical outcomes.

    PMID: 28634619 [PubMed - as supplied by publisher]

  • : CT and MRI findings in focal eosinophilic infiltration of the liver. - pubmed: "medical imaging"
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    CT and MRI findings in focal eosinophilic infiltration of the liver.

    Abdom Radiol (NY). 2017 Jun 20;:

    Authors: Guo BL, Hu QG, Ouyang FS, Zhang B, Dong YH, Luo XN, Lian ZY, Zhang SX

    Abstract
    OBJECTIVES: To investigate the findings of computed tomography (CT) and magnetic resonance imaging (MRI) of focal eosinophilic infiltration (FEI) of the liver.
    METHODS: A retrospective study including 29 patients with confirmed FEI of the liver was performed. We evaluated the lesions' number, distribution, size, shape, margin, attenuation or signal intensity characteristics, the enhancement pattern, and some special features. Spearman correlation analysis was used to analyze the correlation between the number of lesions and the eosinophil counts in peripheral blood.
    RESULTS: In all, 108 lesions were detected in 29 cases, including two cases with single lesion and the remaining 27 cases with multiple lesions. The mean size of all lesions was 34 mm (range, from 3 to 61 mm). 95 (88%) lesions were located in subcapsular parenchyma or surrounding the portal vein. Most (66%) subcapsular lesions were wedge shaped and all lesions surrounding portal vein were round shaped. However, the hepatic parenchymal lesions were irregular or round shaped. All lesions showed ill-defined margins. On pre-contrast CT images, the lesions showed slightly low attenuation or iso-attenuating. On T1-weighted and T2-weighted images, the lesions were slightly iso-/hypointense and hyperintense, respectively. A total of 23 (79.3%) cases were gradually enhanced. Branches of portal vein went through the lesions in all cases; 12 had 'stripe sign' and 16 had 'halo ring sign.' Spearman analysis indicated a significant correlation between the number of lesions and the increased eosinophils in peripheral blood (r = 0.627, p = 0.0003).
    CONCLUSIONS: Special CT and MRI features and increased eosinophils may strongly suggest the diagnosis of FEI of the liver.

    PMID: 28634618 [PubMed - as supplied by publisher]

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